@article{ref1,
title="Changes in cortical protein markers of iron transport with gender, major depressive disorder and suicide",
journal="World journal of biological psychiatry",
year="2019",
author="Dean, Brian and Tsatsanis, Andrew and Lam, Linh Q. and Scarr, Elizabeth and Duce, James A.",
volume="ePub",
number="ePub",
pages="1-8",
abstract="OBJECTIVES: The objective of this study was to determine whether a breakdown in proteins regulating cortical iron homeostasis could be involved in the pathophysiology of mood disorders. <br><br>METHODS: Levels of select proteins responsible for cortical iron transport were quantitated by Western blotting of Brodmann's (BA) areas 6 and 10 from patients with major depressive disorder (n = 13), bipolar disorder (n = 12) and age/sex matched controls (n = 13). <br><br>RESULTS: We found the inactive form of ceruloplasmin was lower in BA 6 from males compared to females. Levels of copper containing ceruloplasmin was lower in BA 6 from suicide completers whilst levels of amyloid precursor protein, TAU and transferrin were higher in BA 10 from those individuals. The level of prion protein was lower in BA 6 from subjects with major depressive disorder. <br><br>CONCLUSIONS: Our data suggests that perturbation in cortical iron transport proteins is not prevalent in mood disorders. By contrast, our data suggests changes in iron transport proteins in BA 6 and BA 10 are present after suicide completion. If these changes were present before death, they could have had a role in the genesis of the contemplation and completion of suicide.<p /> <p>Language: en</p>",
language="en",
issn="1562-2975",
doi="10.1080/15622975.2018.1555377",
url="http://dx.doi.org/10.1080/15622975.2018.1555377"
}