@article{ref1,
title="APOE-ε4 genotype is associated with elevated post-concussion symptoms in military veterans with a remote history of mild traumatic brain injury",
journal="Archives of clinical neuropsychology",
year="2018",
author="Merritt, Victoria C. and Lapira, Kristina M. and Clark, Alexandra L. and Sorg, Scott F. and Werhane, Madeleine L. and Jak, Amy J. and Bondi, Mark William and Schiehser, Dawn M. and Delano-Wood, Lisa",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: We evaluated the influence of the APOE-ε4 allele on post-concussive symptoms in military Veterans with a remote history of mild traumatic brain injury (mTBI). <br><br>METHOD: Participants (N = 77) were administered neuropsychiatric measures, on average, approximately 5 years following their most recent mTBI and provided a DNA sample for APOE genotyping. Veterans were divided into two groups based on their ε4 status (n = 14 ε4+, n = 63 ε4-). The Neurobehavioral Symptom Inventory (NSI) was the primary outcome measure, from which a total score was derived, as well as three symptom clusters (somatic, cognitive, and affective). <br><br>RESULTS: ANCOVAs showed a significant main effect of ε4 genotype on the NSI total score and somatic symptom cluster after adjusting for posttraumatic stress symptoms and mTBI history (p =.019-.028, ηp2 =.064-.073), such that ε4+ Veterans endorsed significantly greater symptoms than ε4- Veterans. <br><br>CONCLUSIONS: Our findings suggest that genetic risk may help to explain the poorer long-term outcomes often observed in this population.<p /> <p>Language: en</p>",
language="en",
issn="0887-6177",
doi="10.1093/arclin/acy082",
url="http://dx.doi.org/10.1093/arclin/acy082"
}