@article{ref1,
title="S100B levels in patients with type 2 diabetes mellitus and co-occurring depressive symptoms",
journal="Depression research and treatment",
year="2018",
author="Katsanou, Panagiota and Tentolouris, Nikolaos and Perrea, Despoina and Katsanos, Spyridon and Ntova, Vasiliki and Antrian, Virginia and Konstantopoulos, Panagiotis and Politis, Antonios",
volume="2018",
number="",
pages="e5304759-e5304759",
abstract="Depression is a comorbid condition in patients with Type 2 Diabetes mellitus (T2DM). S100B, a glia derived protein, is linked to depression and has been suggested as a biomarker for depression outcomes in several populations. However, to date there is no data about S100B levels and depression in patients with T2DM. <i>Objective</i>. We hypothesized that S100B serum levels are increased in patients with T2DM and recently diagnosed, drug-free depressive symptoms, and could be used for the diagnosis of depression in T2DM. <i>Methods</i>. Overall 52 patients (62 ± 12 years, female 66, 7%) with no history of depression deriving from the Diabetes out-patient clinic of our University Hospital underwent a one-to-one interview with a psychiatrist and filled a self-assessment (Zung) questionnaire. Serum S00B levels were compared between 30 (63±12 years, female 66, 7%) diabetic patients without depressive symptoms vs 22 patients (62 ±12 years, female 68, 2%) with T2DM and depressive symptoms. <i>Results</i>. There was no difference in serum levels of S100B between patients with T2DM without depressive symptoms vs diabetic patients suffering from depressive symptoms (2.1 (1.9-10.9) pg/ml vs 2.4 (1.9-14.8) pg/ml, p=0. 637+). Moreover, linear regression analysis did not show any association between lnS100B levels and depressive symptoms (<i>β</i> = 0.084, 95% CI 0.470-0.871, and p=0.552), Zung self-assessment score (<i>β</i> = 0.048, 95% CI -0.024-0.033, and p=0.738), and other patients' characteristics. <i>Conclusions</i>. In patients with T2DM there is no correlation between S100B serum levels and newly detected mild depressive symptoms. The brain biochemistry pathways of depression in T2DM warrant further investigation in a larger scale population.<p /> <p>Language: en</p>",
language="en",
issn="2090-1321",
doi="10.1155/2018/5304759",
url="http://dx.doi.org/10.1155/2018/5304759"
}