@article{ref1,
title="Treatment of military acoustic accidents with N-Acetyl-L-cysteine (NAC)",
journal="International journal of audiology",
year="2019",
author="Rosenhall, Ulf and Skoog, Björn and Muhr, Per",
volume="58",
number="3",
pages="151-157",
abstract="OBJECTIVE: To study if the antioxidant (AO) N-Acetyl-L-cysteine (NAC) reduces the risk of hearing loss after acoustic accidents in humans. <br><br>DESIGN: A retrospective, observational study. STUDY SAMPLE: Personnel of the Swedish Armed Forces (SAF) exposed to military acoustic accidents during a 5 year period. Included in the study were 221 cases (mean age: 22.9 years). Most of the exposures, 84%, were weapon related. NAC (400 mg) was given directly after the accident in 146 cases; 75 had not received NAC. <br><br>RESULTS: The prevalence of hearing thresholds ≥25 dB HL, and the incidence of threshold shifts ≥10 dB, was lower in the NAC group than in the non-NAC group directly after the noise exposure. The deterioration was temporary and not discernable a long time after the accident. The difference was most pronounced in the right ear. The risk reduction to get a temporary hearing loss (TTS), affecting one or both ears was 39% (significant) in the NAC group. <br><br>CONCLUSIONS: The study has demonstrated a significant reduction of the incidence of TTS by the use of NAC. Since cases of both permanent hearing loss (PTS) and noise-induced tinnitus are recruited from cases with TTS, the demonstrated risk reduction indicates a positive effect of NAC.<p /> <p>Language: en</p>",
language="en",
issn="1499-2027",
doi="10.1080/14992027.2018.1543961",
url="http://dx.doi.org/10.1080/14992027.2018.1543961"
}