@article{ref1,
title="Sex-specific association of depressive disorder and transient emotional states with alcohol consumption in male and female alcoholics",
journal="Drug and alcohol dependence",
year="2019",
author="Karpyak, Victor M. and Geske, Jennifer R. and Hall-Flavin, Daniel K. and Loukianova, Larissa L. and Schneekloth, Terry D. and Skime, Michelle K. and Seppala, Marvin and Dawson, George and Frye, Mark A. and Choi, Doo-Sup and Biernacka, Joanna M.",
volume="196",
number="",
pages="31-39",
abstract="BACKGROUND: We assessed the impact of comorbid depression and anxiety disorders as well as positive and negative emotional states on alcohol consumption in alcohol dependent men and women. <br><br>METHODS: Per day alcohol consumption during 90 days before enrolment was assessed by the Time Line Follow Back (TLFB) in 287 men and 156 women meeting DSM-IV-TR criteria for alcohol dependence. Propensity to drink in negative/positive emotional states was assessed using the Inventory of Drug Taking Situations (IDTS). Psychiatric comorbidities, including major depressive disorder (MDD), substance-induced depression (SID), anxiety disorders (AnxD), or substance-induced anxiety (SIA) were identified by Psychiatric Research Interview of Substance and Mood Disorders (PRISM). <br><br>RESULTS: In the combined group, increased number of drinks per day and number of heavy drinking days correlated with increased IDTS scores (all p < 0.0001), while the lifetime history of MDD was associated with fewer drinking days (p = 0.045) but not average number of drinks per day. Male sex was associated with higher alcohol consumption per day (p < 0.0001), but not with the number of drinking days (p > 0.05). Lifetime MDD history was associated with less drinking days (p = 0.0084) and less heavy drinking days (p = 0.021) in alcohol dependent men, while current MDD was associated with higher alcohol use per day in alcohol dependent women (p = 0.044). <br><br>CONCLUSIONS: Our findings suggest that emotional states and lifetime MDD history have sex-specific impact on alcohol use in alcohol dependent men and women. The mechanisms underlying these findings and their relevance to treatment outcomes need to be examined in future studies.<br><br>Copyright © 2019 The Authors. Published by Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0376-8716",
doi="10.1016/j.drugalcdep.2018.12.010",
url="http://dx.doi.org/10.1016/j.drugalcdep.2018.12.010"
}