@article{ref1,
title="The inflammatory potential of diet is related to incident frailty and slow walking in older adults",
journal="Clinical nutrition",
year="2019",
author="Laclaustra, Martín and Rodriguez-Artalejo, Fernando and Guallar-Castillón, Pilar and Banegas, José R. and Graciani, Auxiliadora and García-Esquinas, Esther and López-García, Esther",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Certain foods and dietary patterns have been associated with both inflammation and frailty. As chronic inflammation may play a role in frailty and disability, we examined the association of the inflammatory potential of diet with these outcomes. <br><br>METHODS: Data were taken from 1948 community-dwelling individuals ≥60 years old from the Seniors-ENRICA cohort, who were recruited in 2008-2010 and followed-up through 2012. Baseline diet data, obtained with a validated diet history, was used to calculate Shivappa's Dietary Inflammatory Index (DII), an &quot;a priori&quot; pattern score which is based on known associations of foods and nutrients with inflammation, and Tabung's Empirical Dietary Inflammatory Index (EDII), an &quot;a posteriori&quot; pattern score which was statistically derived from an epidemiological study. At follow-up, incident frailty was assessed with Fried's criteria, and incident limitation in instrumental activities of daily living (IADL) with the Lawton-Brody index. Statistical analyses were performed with logistic regression, and adjusted for the main confounders. <br><br>RESULTS: Compared with individuals in the lowest tertile of DII, those in the highest tertile showed higher risk of frailty (odds ratio [OR] 2.48; 95% confidence interval [CI]: 1.42, 4.44, p-trend = 0.001) and IADL disability (OR: 1.96; 95% CI: 1.03, 3.86, p-trend = 0.035). By contrast, EDII did not show an association with these outcomes. The DII score was associated with slow gait speed, both as a low score in the Short Physical Performance Battery test (OR: 1.82; 95% CI: 1.27, 2.62, p-trend = 0.001) and as a positive Fried's criterion (OR: 1.64; 95% CI: 1.08, 2.51, p-trend = 0.021), which use different thresholds. <br><br>CONCLUSIONS: DII predicted frailty and IADL while EDII did not. DII is able to measure diet healthiness in terms of physical decline in addition to avoidance of inflammation. REGISTERED ON: ClinicalTrials.gov number, NCT01133093.<br><br>Copyright © 2019 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0261-5614",
doi="10.1016/j.clnu.2019.01.013",
url="http://dx.doi.org/10.1016/j.clnu.2019.01.013"
}