@article{ref1,
title="Child maltreatment, adaptive functioning, and polygenic risk: a structural equation mixture model",
journal="Development and psychopathology",
year="2019",
author="Thibodeau, Eric L. and Masyn, Katherine E. and Rogosch, Fred A. and Cicchetti, Dante",
volume="31",
number="2",
pages="443-456",
abstract="This study used a structural equation mixture model to examine associations between child maltreatment, polygenic risk, and indices of adaptive functioning. Children aged 6 to 13 years (N = 1,004), half maltreated, half nonmaltreated, were recruited to attend a research day camp. Multi-informant indicators of prosocial behavior, antisocial behavior, withdrawn behavior, and depression were collected and used in a latent class analysis. Four classes emerged, characterizing &quot;well-adjusted,&quot; &quot;externalizing,&quot; &quot;internalizing,&quot; and &quot;socially dominant&quot; groups. Twelve genetic variants, previously reported in the Gene × Environment literature, were modeled as one weighted polygenic risk score. Large main effects between maltreatment and adaptive functioning were observed (Wald = 35.3, df = 3, p <.0001), along with evidence of a small Gene × Environment effect (Wald = 13.5, df = 3, p =.004), adjusting for sex, age, and covariate interaction effects.<p /> <p>Language: en</p>",
language="en",
issn="0954-5794",
doi="10.1017/S0954579419000014",
url="http://dx.doi.org/10.1017/S0954579419000014"
}