@article{ref1,
title="Health-related quality of life in injury patients: the added value of extending the EQ-5D-3L with a cognitive dimension",
journal="Quality of life research",
year="2019",
author="Ophuis, Robbin H. and Janssen, Mathieu F. and Bonsel, Gouke J. and Panneman, Martien J. and Polinder, Suzanne and Haagsma, Juanita A.",
volume="28",
number="7",
pages="1941-1949",
abstract="INTRODUCTION: The EQ-5D is frequently used to understand the development of health-related quality of life (HRQL) following injury. However, the lack of a cognition dimension is generally felt as disadvantageous as many injuries involve cognitive effects. We aimed to assess the added value of a cognitive dimension in a cohort of injury patients. <br><br>METHODS: We analyzed EQ-5D-3L extended with cognition (EQ-5D + C) dimension responses of 5346 adult injury patients. We studied dimension dependency, assessed the additional effect of the cognitive dimension on the EQ-VAS, and, using the EQ-VAS as a dependent variable, determined the impact of EQ-5D and EQ-5D + C attributes in multivariate regression analyses. <br><br>RESULTS: Extreme cognitive problems combined with no problems on other dimensions are uncommon, whereas severe problems on other dimensions frequently occur without cognitive problems. The EQ-VAS significantly decreased when cognitive problems emerged. Univariate regression analyses indicated that all EQ-5D + C dimensions were significantly associated with the EQ-VAS. Exploratory analyses showed that using any set of five of the six EQ-5D + C dimensions resulted in almost identical explained variance, and adding the remaining 6th dimension resulted in a similar additional impact. <br><br>CONCLUSIONS: The addition of the cognition dimension increased the explanatory power of the EQ-5D-3L. Although the increase in explanatory power was relatively small after the cognition dimension was added, the decrease of HRQoL (measured with the EQ-VAS) resulting from cognitive problems was comparable to the decreases resulting from other EQ-5D dimensions.<p /> <p>Language: en</p>",
language="en",
issn="0962-9343",
doi="10.1007/s11136-019-02156-2",
url="http://dx.doi.org/10.1007/s11136-019-02156-2"
}