@article{ref1,
title="Risk factors for anterior hypopituitarism in patients with traumatic brain injury",
journal="Journal of cranialfacial surgery",
year="2019",
author="You, Wendong and Zhu, Yuanrun and Wen, Liang and Sun, Yun and Pan, Desheng and Yang, Xiaofeng",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Hypopituitarism is a common but potentially undiagnosed complication in patients who suffer traumatic brain injury (TBI). The identification of risk factors of hypopituitarism after TBI is vital to establish a rational testing approach for these patients. <br><br>METHODS: The authors retrospectively reviewed the case records of patients with TBI, who underwent pituitary function evaluation in our department between January 2014 and December 2016. <br><br>RESULTS: In all, 193 patients (66.3% male) hospitalized with TBI were included in this study. Anterior hypopituitarism was observed in 33 (17.1%) patients, with 4.7% of the patients having multiple pituitary axes dysfunction. Patients with hypopituitarism had a longer length of ICU stay (8.7 ± 5.5 versus 3.3 ± 4.6, P < 0.001), longer length of total hospital stay (28.7 ± 20.1 versus 21.0 ± 15.8, P = 0.011), and lower Glasgow coma scale (GCS) on admission (9.1 ± 3.5 versus 11.8 ± 3.6, P < 0.001) than those without the condition. Length of ICU stay (P = 0.004, OR = 1.253) and intracranial hypertension (P = 0.027, OR = 3.206) were independent risk factors for posttraumatic hypopituitarism. <br><br>CONCLUSIONS: The prevalence of anterior hypopituitarism was estimated to be 17.1%. Patients with intracranial hypertension and longer length of ICU stay are at risk of hypopituitarism. Routine pituitary function evaluation is indicated for this group of patients.<p /> <p>Language: en</p>",
language="en",
issn="1049-2275",
doi="10.1097/SCS.0000000000005405",
url="http://dx.doi.org/10.1097/SCS.0000000000005405"
}