@article{ref1,
title="A case of fatal acebutolol poisoning: an illustration of the potential of molecular networking",
journal="International journal of legal medicine",
year="2019",
author="Le Daré, Brendan and Allard, Sophie and Bouvet, Renaud and Baert, Alain and Allard, Pierre-Marie and Morel, Isabelle and Gicquel, Thomas",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Acebutolol is a β1-selective adrenergic receptor antagonist with moderate membrane-stabilizing activity and intrinsic sympathomimetic activity; accordingly, the drug is indicated in hypertension, angina pectoris, and arrhythmia. However, acebutolol's beta-blocking properties also extend the QRS and QTc intervals, and may predispose the patient to ventricular tachydysrhythmia. Here, we report autopsy and toxicological findings on a fatal case of acebutolol self-poisoning in a 70-year-old woman. Toxicological analyses of post-mortem samples (using a liquid chromatography high-resolution mass spectrometry (LC-HR-MS) method) highlighted high concentrations of acebutolol and its metabolite diacetolol in femoral blood (92.8 mg/L and 21.2 mg/L, respectively) and other matrices (cardiac blood, urine, bile, and gastric contents). A molecular networking approach provided useful information on acebutolol's metabolism and revealed the existence of an unknown phase II metabolite of acebutolol. Molecular networking also facilitated visualization of the complex LC-HR-MS/MS datasets and the sample-to-sample comparisons that confirmed massive acebutolol intoxication by ingestion.<p /> <p>Language: en</p>",
language="en",
issn="0937-9827",
doi="10.1007/s00414-019-02062-9",
url="http://dx.doi.org/10.1007/s00414-019-02062-9"
}