@article{ref1,
title="Functional connectivity and the sleep-deprived brain",
journal="Progress in brain research",
year="2019",
author="Chee, Michael W. L. and Zhou, Juan",
volume="246",
number="",
pages="159-176",
abstract="Resting state functional connectivity (rsFC) evaluated by detecting temporal co-variation of BOLD signals across multiple brain regions undergoes three major changes following sleep deprivation that indicate the occurrence of sleep intrusions; a loss of integration within networks like the default mode network as well as between networks like the salience and dorsal attention systems; a loss of segregation between networks, for example, between the dorsal attention and default mode networks; and an increase in global signal. Changes in vigilance affect rsFC and these likely occur in many scans involving persons with neuropsychiatric conditions. Ensuring &quot;healthy&quot; or &quot;control&quot; participants do not fall asleep in the scanner is increasingly acknowledged as a being important for proper inference in fMRI studies. Dynamic functional connectivity analyses evaluating the relative proportion of time spent in &quot;low&quot; or &quot;high&quot; arousal states during the well-rested state can predict propensity for vigilance decline when sleep deprived.<br><br>© 2019 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0079-6123",
doi="10.1016/bs.pbr.2019.02.009",
url="http://dx.doi.org/10.1016/bs.pbr.2019.02.009"
}