@article{ref1,
title="GWAS of suicide attempt in psychiatric disorders and association with major depression polygenic risk scores",
journal="American journal of psychiatry",
year="2019",
author="Mullins, Niamh and Bigdeli, Tim B. and Børglum, Anders D. and Coleman, Jonathan R. I. and Demontis, Ditte and Mehta, Divya and Power, Robert A. and Ripke, Stephan and Stahl, Eli A. and Starnawska, Anna and Anjorin, Adebayo and Corvin, Aiden and Sanders, Alan R. and Forstner, Andreas J. and Reif, Andreas and Koller, Anna C. and Świątkowska, Beata and Baune, Bernhard T. and Müller-Myhsok, Bertram and Penninx, Brenda W. J. H. and Pato, Carlos and Zai, Clement and Rujescu, Dan and Hougaard, David M. and Quested, Digby and Levinson, Douglas F. and Binder, Elisabeth B. and Byrne, Enda M. and Agerbo, Esben and Streit, Fabian and Mayoral, Fermín and Bellivier, Frank and Degenhardt, Franziska and Breen, Gerome and Morken, Gunnar and Turecki, Gustavo and Rouleau, Guy A. and Grabe, Hans J. and Völzke, Henry and Jones, Ian and Giegling, Ina and Agartz, Ingrid and Melle, Ingrid and Lawrence, Jacob and Walters, James T. R. and Strohmaier, Jana and Shi, Jianxin and Hauser, Joanna and Biernacka, Joanna M. and Vincent, John B. and Kelsoe, John and Strauss, John S. and Lissowska, Jolanta and Pimm, Jonathan and Smoller, Jordan W. and Guzman-Parra, Jose and Berger, Klaus and Scott, Laura J. and Jones, Lisa A. and Azevedo, M. Helena and Trzaskowski, Maciej and Kogevinas, Manolis and Rietschel, Marcella and Boks, Marco P. M. and Ising, Marcus and Grigoroiu-Serbanescu, Maria and Hamshere, Marian L. and Leboyer, Marion and Frye, Mark and Nothen, Markus M. and Alda, Martin and Preisig, Martin and Nordentoft, Merete and Boehnke, Michael and O'Donovan, Michael C. and Owen, Michael J. and Pato, Michele T. and Renteria, Miguel E. and Budde, Monika and Weissman, Myrna M. and Wray, Naomi R. and Bass, Nicholas and Craddock, Nicholas and Smeland, Olav B. and Andreassen, Ole A. and Mors, Ole and Gejman, Pablo V. and Sklar, Pamela and McGrath, Patrick and Hoffmann, Per and McGuffin, Peter and Lee, Phil H. and Mortensen, Preben Bo and Kahn, Rene S. and Ophoff, Roel A. and Adolfsson, Rolf and Van der Auwera, Sandra and Djurovic, Srdjan and Kloiber, Stefan and Heilmann-Heimbach, Stefanie and Jamain, Stéphane and Hamilton, Steven P. and McElroy, Susan L. and Lucae, Susanne and Cichon, Sven and Schulze, Thomas G. and Hansen, Thomas and Werge, Thomas and Air, Tracy M. and Nimgaonkar, Vishwajit and Appadurai, Vivek and Cahn, Wiepke and Milaneschi, Yuri and Fanous, Ayman H. and Kendler, Kenneth S. and McQuillin, Andrew and Lewis, Cathryn M.",
volume="176",
number="8",
pages="651-660",
abstract="OBJECTIVE: More than 90% of people who attempt suicide have a psychiatric diagnosis; however, twin and family studies suggest that the genetic etiology of suicide attempt is partially distinct from that of the psychiatric disorders themselves. The authors present the largest genome-wide association study (GWAS) on suicide attempt, using cohorts of individuals with major depressive disorder, bipolar disorder, and schizophrenia from the Psychiatric Genomics Consortium. <br><br>METHODS: The samples comprised 1,622 suicide attempters and 8,786 nonattempters with major depressive disorder; 3,264 attempters and 5,500 nonattempters with bipolar disorder; and 1,683 attempters and 2,946 nonattempters with schizophrenia. A GWAS on suicide attempt was performed by comparing attempters to nonattempters with each disorder, followed by a meta-analysis across disorders. Polygenic risk scoring was used to investigate the genetic relationship between suicide attempt and the psychiatric disorders. <br><br>RESULTS: Three genome-wide significant loci for suicide attempt were found: one associated with suicide attempt in major depressive disorder, one associated with suicide attempt in bipolar disorder, and one in the meta-analysis of suicide attempt in mood disorders. These associations were not replicated in independent mood disorder cohorts from the UK Biobank and iPSYCH. No significant associations were found in the meta-analysis of all three disorders. Polygenic risk scores for major depression were significantly associated with suicide attempt in major depressive disorder (R<sup>2</sup>=0.25%), bipolar disorder (R<sup>2</sup>=0.24%), and schizophrenia (R<sup>2</sup>=0.40%). <br><br>CONCLUSIONS: This study provides new information on genetic associations and demonstrates that genetic liability for major depression increases risk for suicide attempt across psychiatric disorders. Further collaborative efforts to increase sample size may help to robustly identify genetic associations and provide biological insights into the etiology of suicide attempt.<p /> <p>Language: en</p>",
language="en",
issn="0002-953X",
doi="10.1176/appi.ajp.2019.18080957",
url="http://dx.doi.org/10.1176/appi.ajp.2019.18080957"
}