@article{ref1,
title="Major depressive disorder-associated SIRT1 locus affects the risk for suicide in women after middle age",
journal="Psychiatry research",
year="2019",
author="Hirata, Takashi and Otsuka, Ikuo and Okazaki, Satoshi and Mouri, Kentaro and Horai, Tadasu and Boku, Shuken and Takahashi, Motonori and Ueno, Yasuhiro and Sora, Ichiro and Shirakawa, Osamu and Hishimoto, Akitoyo",
volume="278",
number="",
pages="141-145",
abstract="A recent genome-wide association study (GWAS) for major depressive disorder (MDD) in Chinese women identified a single-nucleotide polymorphism (SNP), rs12415800, near the Sirtuin1 (SIRT1) gene as one of the top candidate loci. However, no study has shown a genetic association between SIRT1 and completed suicide, which is one of the most serious outcomes of MDD. In this study, 778 suicide completers and 760 controls in a Japanese population were genotyped for two SNPs in strong linkage disequilibrium (rs12415800 and rs4746720 in 3'UTR). We found significant associations between both SNPs and completed suicide among women aged ≥50 years. Additional analysis using postmortem brain tissues (10 suicide brains and 13 non-suicide brains) revealed the following: while SIRT1 gene expression in the prefrontal cortex did not differ between suicide and non-suicide brains, DNAJC12 gene expression, potentially implicated by the SNPs genotyped here, was significantly decreased in suicide brains (p = 0.003). In conclusion, regarding the genetic association of SIRT1 with MDD that was previously identified in women by the Chinese GWAS, we successfully validated our results using a female suicidal cohort in the same Asian population with the same direction of allelic effect.<br><br>Copyright © 2019 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0165-1781",
doi="10.1016/j.psychres.2019.06.002",
url="http://dx.doi.org/10.1016/j.psychres.2019.06.002"
}