@article{ref1,
title="Venoms and isolated toxins from snakes of medical impact in the Northeast Argentina: state of the art. Potential pharmacological applications",
journal="Current topics in medicinal chemistry",
year="2019",
author="Garcia Denegri, María Emilia and Bustillo, Soledad and Gay, Claudia Carolina and Van De Velde, Andrea and Gomez, Gabriela and Echeverría, Silvina and Gauna Pereira, María Del Carmen and Maruñak, Silvana and Nuñez, Sandra and Bogado, Fabián and Sanchez, Matías and Teibler, Gladys Pamela and Fusco, Luciano and Leiva, Laura Cristina Ana",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Among the ophidians that inhabit the Northeast of Argentina, the genus Bothrops such as B. alternatus and B. diporus species (also known as yararás) and Crotalus durisus terrificus (named cascabel), represent the most studied snake venom for more than thirty years. These two genera of venomous snakes account for the majority of poisonous snake envenomations and therefore constitute a medical emergency in this region. This review presents a broad description of the compiled knowledge about venomous snakebite: its pathophysiological action, protein composition, isolated toxins, toxin synergism, toxin-antitoxin cross-reaction assays. Properties of some isolated toxins support a potential pharmacological application.<br><br>Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.<p /> <p>Language: en</p>",
language="en",
issn="1568-0266",
doi="10.2174/1568026619666190725094851",
url="http://dx.doi.org/10.2174/1568026619666190725094851"
}