@article{ref1,
title="Biomarkers for REM sleep behavior disorder in idiopathic and narcoleptic patients",
journal="Annals of clinical and translational neurology",
year="2019",
author="Antelmi, Elena and Pizza, Fabio and Donadio, Vincenzo and Filardi, Marco and Sosero, Yuri L. and Incensi, Alex and Vandi, Stefano and Moresco, Monica and Ferri, Raffaele and Marelli, Sara and Ferini-Strambi, Luigi and Liguori, Rocco and Plazzi, Giuseppe",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="To search for discriminating biomarkers, 30 patients with idiopathic rapid-eye-movements sleep behavior disorder (iRBD) were compared with 17 patients with RBD within narcolepsy type 1. Both groups underwent extensive examinations, including skin biopsy searching for phosphorylated α-synuclein deposits and whole-night video-polysomnography. Skin biopsy was positive for phosphorylated α-synuclein deposits in 86.7% of iRBD patients and in none of narcoleptic patients. The analysis of video-polysomnographic motor events showed differences in their occurrence throughout the night in the two groups. iRBD and RBD due to narcolepsy do have different clinical and pathological findings, confirming a different pathophysiology.<br><br>© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.<p /> <p>Language: en</p>",
language="en",
issn="2328-9503",
doi="10.1002/acn3.50833",
url="http://dx.doi.org/10.1002/acn3.50833"
}