@article{ref1,
title="Association between carotid artery intima-media thickness and combinations of mild cognitive impairment and pre-frailty in older adults",
journal="International journal of environmental research and public health",
year="2019",
author="Park, Jinkee and Park, Jong-Hwan and Park, Hyuntae",
volume="16",
number="16",
pages="e16162978-e16162978",
abstract="Carotid intima-media thickness (CIMT) has been proposed as a surrogate marker of cardiovascular disease. Mild cognitive impairment (MCI) and pre-frailty are reportedly associated with increased CIMT. As the evidence on the association of CIMT with combinations of MCI and pre-frailty is limited, this association is examined. A total of 231 older adults participated. MCI was defined according to clinical consensus or psychometric criteria by a dementia specialist, and considering detailed neuropsychological assessments. Also, pre-frailty was defined as subjects with frail component of 1 or 2. Carotid variables were measured using a B-mode ultrasound. The analysis of covariance (ANCOVA) was performed to assess independent differences in CIMT among the four groups, according to the cognitive function and frailty status after a multivariate adjustment. Increased CIMT is associated with combinations of MCI and pre-frailty. ANCOVA showed that CIMTs were significantly different among the four groups according to the cognitive function and frailty status. CIMTmax combined with MCI and pre-frailty was the thickest (1.04 ± 0.3 mm), whereas the CIMT of no MCI and no pre-frailty was the thinnest (0.82 ± 0.2 mm). The results suggest that combinations of MCI and pre-frailty are associated with increased CIMT in older adults.<p /> <p>Language: en</p>",
language="en",
issn="1661-7827",
doi="10.3390/ijerph16162978",
url="http://dx.doi.org/10.3390/ijerph16162978"
}