@article{ref1,
title="Cannabis intoxication after accidental ingestion in infants: urine and plasma concentrations of Δ-9-tetrahydrocannabinol (THC), THC-COOH and 11-OH-THC in 10 patients",
journal="Clinical toxicology (Philadelphia, Pa.)",
year="2019",
author="Guidet, Charles and Gregoire, Matthieu and Le Dreau, Alexiane and Vrignaud, Bénédicte and Deslandes, Guillaume and Monteil-Ganière, Catherine",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="<b>Introduction:</b> Accidental cannabis poisoning after oral ingestion in infants is an emerging cause of intoxication with well-known clinical aspects but few data exist regarding the levels of cannabinoids in plasma and urine. Here, we present data on the concentrations of Δ-9-tetrahydrocannabinol (THC) and metabolites in plasma and/or urine in 10 infants after cannabis intoxication. <b>Materials and methods:</b> Cannabinoids were detected using an automated immunochemical method and quantified using liquid chromatography coupled with mass spectrometry. <b>Results:</b> Ten infants were admitted after cannabis poisoning. THC, THC-COOH and 11-OH-THC plasma levels ranged from 4.4 to 127 ng/mL, from 28 to 433 ng/mL and from 2 to 59.8 ng/mL, respectively. THC-COOH urine levels ranged from 748 to 5689 ng/mL. The most common symptoms were drowsiness, hypotonia, behavioural disorder and tachycardia. <b>Discussion:</b> No correlation between plasma concentrations and symptoms could be found, but the concentration of THC-COOH in the two patients who experienced seizures was higher than 3000 ng/mL. This series of cases of accidental intoxication in infants showed high THC and metabolites concentrations in urine and plasma.<p /> <p>Language: en</p>",
language="en",
issn="1556-3650",
doi="10.1080/15563650.2019.1655569",
url="http://dx.doi.org/10.1080/15563650.2019.1655569"
}