@article{ref1,
title="Frailty index as a predictor of all-cause and cause-specific mortality in a Swedish population-based cohort",
journal="Aging (Albany NY)",
year="2017",
author="Jiang, Miao and Foebel, Andrea Dawn and Kuja-Halkola, Ralf and Karlsson, Ida and Pedersen, Nancy Lee and Hägg, Sara and Jylhävä, Juulia",
volume="9",
number="12",
pages="2629-2646",
abstract="Frailty is a complex manifestation of aging and associated with increased risk of mortality and poor health outcomes. However, younger individuals (under 65 years) are less-studied in this respect. Also, the relationship between frailty and cause-specific mortality in community settings is understudied. We used a 42-item Rockwood-based frailty index (FI) in the Swedish Adoption/Twin Study of Aging (n=1477; 623 men, 854 women; aged 29-95 years) and analyzed its association with all-cause and cause-specific mortality in up to 30-years of follow-up. Deaths due to cardiovascular disease (CVD), cancer, dementia and other causes were considered as competing risks. The FI was independently associated with increased risk for all-cause mortality in younger (<65 years; HR per increase in one deficit 1.11, 95%CI 1.07-1.17) and older (≥65 years; HR 1.07, 95%CI 1.04-1.10) women and in younger men (HR 1.05, 95%CI 1.01-1.10). In cause-specific mortality analysis, the FI was strongly predictive of CVD mortality in women (HR per increase in one deficit 1.13, 95%CI 1.09-1.17), whereas in men the risk was restricted to deaths from other causes (HR 1.07, 95%CI 1.01-1.13). In conclusion, the FI is a strong mortality predictor especially among younger individuals and its associations with cause-specific mortality are sex-specific.<p /><p>Language: en</p>",
language="en",
issn="1945-4589",
doi="10.18632/aging.101352",
url="http://dx.doi.org/10.18632/aging.101352"
}