@article{ref1,
title="Altered amygdala subregion-related circuits in treatment-naïve post-traumatic stress disorder comorbid with major depressive disorder",
journal="European Neuropsychopharmacology",
year="2019",
author="Yuan, Minlan and Pantazatos, Spiro P. and Zhu, Hongru and Li, Yuchen and Miller, Jeffrey M. and Rubin-Falcone, Harry and Zanderigo, Francesca and Ren, Zhengjia and Yuan, Cui and Lui, Su and Gong, Qiyong and Qiu, Changjian and Zhang, Wei and John Mann, J.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Individuals with both post-traumatic stress disorder and major depressive disorder (PTSD+MDD) often show greater social and occupational impairment and poorer treatment response than individuals with PTSD alone. Increasing evidence reveals that the amygdala, a brain region implicated in the pathophysiology of both of these conditions, is a complex of structurally and functionally heterogeneous nuclei. Quantifying the functional connectivity of two key amygdala subregions, the basolateral (BLA) and centromedial (CMA), in PTSD+MDD and PTSD-alone could advance our understanding of the neurocircuitry of these conditions. 18 patients with PTSD+MDD, 28 with PTSD-alone, and 50 trauma exposed healthy controls (TEHC), all from a cohort who survived the same large earthquake in China, underwent resting-state functional magnetic resonance imaging. Bilateral BLA and CMA functional connectivity (FC) maps were created using a seed-based approach for each participant. The analysis of covariance of FC was used to determine between-group differences. A significant interaction between amygdala subregion and diagnostic group suggested that differences in connectivity patterns between the two seeds were mediated by diagnosis. Post-hoc analyses revealed that PTSD+MDD patients showed weaker connectivity between right BLA and (a) left anterior cingulate cortex/supplementary motor area, and (b) bilateral putamen/pallidum, compared with PTSD-alone patients. Higher CMA connectivities left ACC/SMA were also observed in PTSD+MDD compared with PTSD-alone. An inverse relationship between the connectivity of right BLA with right putamen/pallidum and MDD symptoms was found in PTSD+MDD. These findings indicate a relationship between the neural pathophysiology of PTSD+MDD compared with PTSD-alone and TEHC and may inform future clinical interventions.<br><br>Copyright © 2019. Published by Elsevier B.V.<p /> <p>Language: en</p>",
language="en",
issn="0924-977X",
doi="10.1016/j.euroneuro.2019.07.238",
url="http://dx.doi.org/10.1016/j.euroneuro.2019.07.238"
}