@article{ref1,
title="Loss of consciousness and altered mental state as predictors of functional recovery within 6 months following mild traumatic brain injury",
journal="Journal of neuropsychiatry and clinical neurosciences",
year="2019",
author="Roy, Durga and Peters, Matthew E. and Everett, Allen D. and Leoutsakos, Jeannie-Marie Sheppard and Yan, Haijuan and Rao, Vani and Bechtold, Kathleen T. and Sair, Haris I. and Van Meter, Tim and Falk, Hayley and Vassila, Alexandra and Hall, Anna and Ofoche, Uju and Akbari, Freshta and Lyketsos, Constantine and Korley, Frederick",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: The authors tested the hypothesis that a combination of loss of consciousness (LOC) and altered mental state (AMS) predicts the highest risk of incomplete functional recovery within 6 months after mild traumatic brain injury (mTBI), compared with either condition alone, and that LOC alone is more strongly associated with incomplete recovery, compared with AMS alone. <br><br>METHODS: Data were analyzed from 407 patients with mTBI from <i>Head</i> injury <i>S</i>erum <i>M</i>arkers for <i>A</i>ssessing <i>R</i>esponse to <i>T</i>rauma (HeadSMART), a prospective cohort study of TBI patients presenting to two urban emergency departments. Four patient subgroups were constructed based on information documented at the time of injury: neither LOC nor AMS, LOC only, AMS only, and both. Logistic regression models assessed LOC and AMS as predictors of functional recovery at 1, 3, and 6 months. <br><br>RESULTS: A gradient of risk of incomplete functional recovery at 1, 3, and 6 months postinjury was noted, moving from neither LOC nor AMS, to LOC or AMS alone, to both. LOC was associated with incomplete functional recovery at 1 and 3 months (odds ratio=2.17, SE=0.46, p<0.001; and odds ratio=1.80, SE=0.40, p=0.008, respectively). AMS was associated with incomplete functional recovery at 1 month only (odds ratio=1.77, SE=0.37 p=0.007). No association was found between AMS and functional recovery in patients with no LOC. Neither LOC nor AMS was predictive of functional recovery at later times. <br><br>CONCLUSIONS: These findings highlight the need to include symptom-focused clinical variables that pertain to the injury itself when assessing who might be at highest risk of incomplete functional recovery post-mTBI.<p /> <p>Language: en</p>",
language="en",
issn="0895-0172",
doi="10.1176/appi.neuropsych.18120379",
url="http://dx.doi.org/10.1176/appi.neuropsych.18120379"
}