@article{ref1,
title="Family history of alcohol use disorder is associated with brain structural and functional changes in healthy first-degree relatives",
journal="European psychiatry",
year="2019",
author="Filippi, Irina and Hoertel, Nicolas and Artiges, Eric and Airagnes, Guillaume and Guérin-Langlois, Christophe and Seigneurie, Anne-Sophie and Frère, Pauline and Dubol, Manon and Guillon, François and Lemaitre, Herve and Rahim, Mehdi and Martinot, Jean-Luc and Limosin, Frederic",
volume="62",
number="",
pages="107-115",
abstract="BACKGROUND: Neuroimaging studies of vulnerability to Alcohol Use Disorder (AUD) have identified structural and functional variations which might reflect inheritable features in alcohol-naïve relatives of AUD individuals (FH+) compared to controls having no such family history (FH-). However, prior research did not simultaneously account for childhood maltreatment, any clinically significant disorder and maternal AUD. Therefore, we mainly aimed to investigate the brain structure and reward-related neural activations (fMRI), using whole-brain analysis in FH+ young adults with no prevalent confounders. <br><br>METHODS: 46 FH+ and 45 FH- male and female participants had no severe childhood maltreatment exposure, neither any psychiatric disorder or AUD, nor a prenatal exposure to maternal AUD. We used a 3 T MRI coupled with a whole brain voxel-based method to compare between groups the grey matter volumes and activations in response to big versus small wins during a Monetary Incentive Delay task. The Childhood Trauma Questionnaire score was used as confounding variable in the analyses to account for the remaining variance between groups. <br><br>RESULTS: Compared to FH- controls, FH+ participants had smaller grey matter volumes in the frontal and cingulate regions as well as in the bilateral nucleus accumbens and right insula. The FH+ participants' fMRI datasets denoted a blunted activation in the middle cingulum with respect to FH- controls' during the processing of reward magnitude, and a greater activation in the anterior cingulum in response to anticipation of a small win. <br><br>CONCLUSIONS: Family history of alcohol use disorder is linked to structural and functional variations including brain regions involved in reward processes.<br><br>Copyright © 2019. Published by Elsevier Masson SAS.<p /> <p>Language: en</p>",
language="en",
issn="0924-9338",
doi="10.1016/j.eurpsy.2019.08.003",
url="http://dx.doi.org/10.1016/j.eurpsy.2019.08.003"
}