@article{ref1,
title="An activatable NIR-II nanoprobe for in vivo early real-time diagnosis of traumatic brain injury",
journal="Angewandte Chemie (International ed. in English)",
year="2019",
author="Wang, Qiangbin and Li, Chunyan and Li, Wanfei and Li, Zijing and Zhang, Yejun and Chen, Guangcun and Liu, Huanhuan",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Traumatic brain injury (TBI) is one of the most dangerous acute diseases resulting in high morbidity and mortality. Current methods remain limited with respect to early diagnosis and real-time feedback on the pathological process. Herein, a targeted activatable fluorescent nanoprobe (V&A@Ag 2 S) in the second near-infrared window (NIR-II) is presented for  in vivo  optical imaging of TBI. Initially, the fluorescence of V&A@Ag 2 S displays an &quot;off&quot; state owing to energy transfer from Ag 2 S to the A1094 chromophore. Upon intravenous injection, V&A@Ag 2 S quickly accumulates in the inflamed vascular endothelium of TBI based on VCAM1-mediated endocytosis, after which the nanoprobe achieves rapid recovery of the NIR-II fluorescence of Ag 2 S quantum dots (QDs) due to the bleaching of A1094 by the prodromal biomarker of TBI, peroxynitrite (ONOO -  ). Taking advantage of the deep tissue penetration and high signal-to-noise ratio of NIR-II fluorescence imaging, this nanoprobe offers high specificity, rapid response, and high sensitivity toward ONOO - , providing a convenient approach for  in vivo  early real-time assessment of TBI.<br><br>© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.<p /> <p>Language: en</p>",
language="en",
issn="1433-7851",
doi="10.1002/anie.201911803",
url="http://dx.doi.org/10.1002/anie.201911803"
}