@article{ref1,
title="Snakebite envenoming in French Guiana: assessment of the preclinical efficacy against the venom of Bothrops atrox of two polyspecific antivenoms",
journal="Toxicon: Journal of the International Society on Toxinology",
year="2019",
author="Résière, Dabor and Villalta, Mauren and Arias, Ana Silvia and Kallel, Hatem and Nèviére, Rémi and Vidal, Nicolas and Mehdaoui, Hossein and Gutiérrez, José María",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Snakebite envenoming is a relevant public health problem in French Guiana, and Bothrops atrox is responsible for the vast majority of envenomings in this overseas French territory. The preclinical efficacy of freeze-dried antivenoms manufactured in Costa Rica (Polival-ICP®) and Mexico (Antivipmyn Tri®) was assessed against the lethal, hemorrhagic, in vitro coagulant, and myotoxic effects of Bothrops atrox venom from French Guiana. Antivenoms differ in protein concentration and in the type of active principle (IgG and F(ab')<sub>2</sub>, respectively). Polival-ICP® showed significantly higher neutralizing activity against lethal, hemorrhagic and in vitro coagulant activities of the venom. Antivenoms neutralized myotoxic effect to a similar extent. In the case of lethal activity, Antivipmyn Tri® did not neutralize the effect at the highest antivenom level tested (1 mg venom/mL antivenom).<br><br>Copyright © 2019. Published by Elsevier Ltd.<p /> <p>Language: en</p>",
language="en",
issn="0041-0101",
doi="10.1016/j.toxicon.2019.11.001",
url="http://dx.doi.org/10.1016/j.toxicon.2019.11.001"
}