@article{ref1,
title="Isotopomics by isotope ratio monitoring by <sup>13</sup> C Nuclear Magnetic Resonance Spectrometry on cutting agents in heroin: a new approach for illicit drugs trafficking route elucidation",
journal="Drug testing and analysis",
year="2019",
author="Joubert, Valentin and Trébuchet, Matéo and Mikic, Mariana and Silvestre, Virginie and Schiphorst, Anne-Marie and Loquet, Denis and Stemmelen, Anaïs and Ladroue, Virginie and Besacier, Fabrice and Akoka, Serge and Remaud, Gérald S.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="In the battle against the illicit drugs market, methodologies have been developed by forensic laboratories to address origin determination and trafficking route dismantlement for various target molecules such as heroin and cocaine. These drug profiling methods are not straightforward especially when the target molecules are synthetic and very pure, resulting in poorly informative impurity profiles, e.g. New Psychoactive Substances and cutting agents. A tool based on the determination of intramolecular isotopic profiles has been developed to provide origin discrimination with a new way to profile seized cutting agents and heroin samples. Whereas stable isotope analyses by Mass Spectrometry give the bulk isotopic composition, Nuclear Magnetic Resonance gives direct access to the position-specific isotope content at natural abundance. In this report, it is shown how both <sup>13</sup> C NMR spectrometry and <sup>13</sup> C, <sup>15</sup> N MS might provide complementary and valuable information to link seized caffeine and paracetamol to their origin. Here, isotopic ratio monitoring by <sup>13</sup> C NMR (irm-<sup>13</sup> C NMR) offers additional benefits over irm-MS in its capability to determine a detailed isotopic profile, leading to a better method to distinguish different caffeine and paracetamol batches.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="1942-7603",
doi="10.1002/dta.2745",
url="http://dx.doi.org/10.1002/dta.2745"
}