@article{ref1,
title="Increased circulatory IL-6 during 8-week fluoxetine treatment is a risk factor for suicidal behaviors in youth",
journal="Brain, behavior, and immunity",
year="2019",
author="Amitai, Maya and Taler, Michal and Ben-Baruch, Reut and Lebow, Maya and Rotkopf, Ron and Apter, Alan and Fennig, Silvana and Weizman, Abraham and Chen, Alon",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: Selective serotonin reuptake inhibitors (SSRIs) are commonly used to treat anxiety and/or depression in pediatric populations. However, the response rates are low (approximately 50%). Moreover, SSRI use is frequently associated with adverse events (AE). Currently there are no available biomarkers for treatment response/AE. Identification of biomarkers predicting early response and/or AE could help maximize the benefit-risk ratio for the use of SSRIs, and accelerate matching of treatments to patients. Pro-inflammatory cytokines were proposed as potential biomarkers. <br><br>METHOD: Ninety-two patients (35 boys and 57 girls) with major depressive disorder or anxiety disorders, aged 13.90 ± 2.41 years, were treated with fluoxetine (FLX) for 8 weeks. Plasma concentrations of TNFα, IL-6, and IL-1β were measured by enzyme linked immunosorbent assays before and after FLX treatment. Clinical response and AE were measured using several clinical scales, including the Clinical Global Impression - improvement, Children's Depression Rating Scale-Revised, the Beck Depression Inventory, the Screen for Child Anxiety Related Emotional Disorders, the Columbia suicide severity rating scale, and the Suicide Ideation Questionnaire. <br><br>RESULTS: IL-6 levels increased after treatment only in the group of children who developed FLX-associated suicidality. <br><br>CONCLUSION: An increase in IL-6 levels during treatment may be a risk factor for the emergence of FLX-associated suicidality (OR=1.70). Further studies are necessary to clarify the role and mechanism(s) of this cytokine in the pathogenesis of this life-threatening AE.<br><br>Copyright © 2019. Published by Elsevier Inc.<p /> <p>Language: en</p>",
language="en",
issn="0889-1591",
doi="10.1016/j.bbi.2019.12.017",
url="http://dx.doi.org/10.1016/j.bbi.2019.12.017"
}