@article{ref1,
title="The anti-fatigue and anti-anoxia effects of Tremella extract",
journal="Saudi journal of biological sciences.",
year="2019",
author="Yang, Dongsheng and Lian, Junhui and Wang, Lanying and Liu, Xiaomei and Wang, Yanzhen and Zhao, Xi and Zhang, Xiaoming and Hu, Wenzhong",
volume="26",
number="8",
pages="2052-2056",
abstract="OBJECTIVE: The present study intended to explore the anti-fatigue and anti-hypoxia efficacy of Tremella extract in mouse model. <br><br>METHODS: Kunming mice were randomized into 5 groups randomly (n = 12/group; half male and female), and given 0.9%Nacl (10 mL/Kg Serving as blank control group)orally, 0.6 g/kg rhodiola capsule (Serving as positive group) and Tremella extract at doses of high (3.0 g/kg), middle (1.5 g/kg) and low (0.5 g/kg) once a day for 14 days. At the end of drug intragastric gavage, following endurance running test, rotating rod test, normobarie hypoxia test and sodium nitrite poisoning test were performed. <br><br>RESULT: 14-day Tremella extract administration fails to influence mouse horizontal and vertical movement indicating little neurotoxicity at chosen doses. Through rotating rod, forced running test, the anti-fatigue activity of Tremella extract was demonstrated. Via normobarie hypoxia test, sodium nitrite poisoning test, Tremella extract was confirmed to possess anti-hypoxia effect. Tremella extract treatment significantly enhanced the liver levels of superoxide dismutase (SOD), and glutathione peroxidase (GSH-Px), increased the expressions of ATP and hepatic glycogen, muscle glycogen in tissue. <br><br>CONCLUSION: We conclude that Tremella extract efficiently enhances mouse fatigue endurance and anti-hypoxia capability partly through energy reserves and antioxidant enzyme activity.<br><br>© 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.<p /> <p>Language: en</p>",
language="en",
issn="1319-562X",
doi="10.1016/j.sjbs.2019.08.014",
url="http://dx.doi.org/10.1016/j.sjbs.2019.08.014"
}