@article{ref1,
title="Kawasaki disease following severe sunburn injury",
journal="Frontiers in pediatrics",
year="2020",
author="Okada, Seigo and Hashimoto, Shintaro and Miyake, Akiko and Okada, Yusuke and Hirano, Reiji and Fukunaga, Shinnosuke and Ishikawa, Yuichi",
volume="8",
number="",
pages="e6-e6",
abstract="<b>Background:</b> Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis. Various etiological pathogens have been proposed as the trigger of KD and a scaled injury preceding symptom onset has been reported as one of them. Here, we report a 17-month-old Japanese female who was hospitalized due to high fever lasting for 4 days with infection ruled out as a cause. On admission, she displayed severe sunburn all over her body following a prolonged period of outdoor play 5 days ago. On the 5 day of illness, she developed complete KD. Serum levels of high mobility group box 1, a representative for damage-associated molecular patterns (DAMPs), were elevated during acute phase and continued to decrease during subacute phase. This unique course suggested the inflammatory process of KD involving innate immunity via DAMPs.<br><br>Copyright © 2020 Okada, Hashimoto, Miyake, Okada, Hirano, Fukunaga and Ishikawa.<p /> <p>Language: en</p>",
language="en",
issn="2296-2360",
doi="10.3389/fped.2020.00006",
url="http://dx.doi.org/10.3389/fped.2020.00006"
}