@article{ref1,
title="Genomic influences on self-reported childhood maltreatment",
journal="Translational psychiatry",
year="2020",
author="Dalvie, Shareefa and Maihofer, Adam X. and Coleman, Jonathan R. I. and Bradley, Bekh and Breen, Gerome and Brick, Leslie Ann and Chen, Chia-Yen and Choi, Karmel W. and Duncan, Laramie E. and Guffanti, Guia and Haas, Magali and Harnal, Supriya and Liberzon, Israel and Nugent, Nicole R. and Provost, Allison C. and Ressler, Kerry J. and Torres, Katy and Amstadter, Ananda B. and Bryn Austin, S. and Baker, Dewleen G. and Bolger, Elizabeth A. and Bryant, Richard A. and Calabrese, Joseph R. and Delahanty, Douglas L. and Farrer, Lindsay A. and Feeny, Norah C. and Flory, Janine D. and Forbes, David and Galea, Sandro and Gautam, Aarti and Gelernter, Joel and Hammamieh, Rasha and Jett, Marti and Junglen, Angela G. and Kaufman, Milissa L. and Kessler, Ronald C. and Khan, Alaptagin and Kranzler, Henry R. and Lebois, Lauren A. M. and Marmar, Charles and Mavissakalian, Matig R. and McFarlane, Alexander and Donnell, Meaghan O' and Orcutt, Holly K. and Pietrzak, Robert H. and Risbrough, Victoria B. and Roberts, Andrea L. and Rothbaum, Alex O. and Roy-Byrne, Peter P. and Ruggiero, Ken and Seligowski, Antonia V. and Sheerin, Christina M. and Silove, Derrick and Smoller, Jordan W. and Stein, Murray B. and Teicher, Martin H. and Ursano, Robert J. and Van Hooff, Miranda and Winternitz, Sherry and Wolff, Jonathan D. and Yehuda, Rachel and Zhao, Hongyu and Zoellner, Lori A. and Stein, Dan J. and Koenen, Karestan C. and Nievergelt, Caroline M.",
volume="10",
number="1",
pages="e38-e38",
abstract="Childhood maltreatment is highly prevalent and serves as a risk factor for mental and physical disorders. Self-reported childhood maltreatment appears heritable, but the specific genetic influences on this phenotype are largely unknown. The aims of this study were to (1) identify genetic variation associated with self-reported childhood maltreatment, (2) estimate SNP-based heritability (h<sup>2</sup><sub>snp</sub>), (3) assess predictive value of polygenic risk scores (PRS) for childhood maltreatment, and (4) quantify genetic overlap of childhood maltreatment with mental and physical health-related phenotypes, and condition the top hits from our analyses when such overlap is present. Genome-wide association analysis for childhood maltreatment was undertaken, using a discovery sample from the UK Biobank (UKBB) (n = 124,000) and a replication sample from the Psychiatric Genomics Consortium-posttraumatic stress disorder group (PGC-PTSD) (n = 26,290). h<sup>2</sup><sub>snp</sub> for childhood maltreatment and genetic correlations with mental/physical health traits were calculated using linkage disequilibrium score regression. PRS was calculated using PRSice and mtCOJO was used to perform conditional analysis. Two genome-wide significant loci associated with childhood maltreatment (rs142346759, p = 4.35 × 10<sup>-8</sup>, FOXP1; rs10262462, p = 3.24 × 10<sup>-8</sup>, FOXP2) were identified in the discovery dataset but were not replicated in PGC-PTSD. h<sup>2</sup><sub>snp</sub> for childhood maltreatment was ~6% and the PRS derived from the UKBB was significantly predictive of childhood maltreatment in PGC-PTSD (r<sup>2</sup> = 0.0025; p = 1.8 × 10<sup>-15</sup>). The most significant genetic correlation of childhood maltreatment was with depressive symptoms (r<sub>g</sub> = 0.70, p = 4.65 × 10<sup>-40</sup>), although we show evidence that our top hits may be specific to childhood maltreatment. This is the first large-scale genetic study to identify specific variants associated with self-reported childhood maltreatment. Speculatively, FOXP genes might influence externalizing traits and so be relevant to childhood maltreatment. Alternatively, these variants may be associated with a greater likelihood of reporting maltreatment. A clearer understanding of the genetic relationships of childhood maltreatment, including particular abuse subtypes, with a range of phenotypes, may ultimately be useful in in developing targeted treatment and prevention strategies.<p /> <p>Language: en</p>",
language="en",
issn="2158-3188",
doi="10.1038/s41398-020-0706-0",
url="http://dx.doi.org/10.1038/s41398-020-0706-0"
}