@article{ref1,
title="Step toward roadside sensing: noninvasive detection of a THC metabolite from the sweat content of fingerprints",
journal="ACS sensors",
year="2019",
author="Brunelle, Erica and Thibodeau, Brenna and Shoemaker, Alyssa and Halámek, Jan",
volume="4",
number="12",
pages="3318-3324",
abstract="The sudden increase in states legalizing marijuana has forced law enforcement into a situation where the use and consumption are legal, but there are no limitations for what is acceptable for driving or operating machinery. Using ultraviolet-visible (UV-vis) spectroscopy, fingerprints from volunteers who had used marijuana were analyzed via a competitive immunoassay for the detection of Δ<sup>9</sup>-tetrahydrocannabinol (Δ<sup>9</sup>-THC), the main psychoactive component of marijuana, and 11-nor-9-carboxy-THC (THC-COOH), one of the main metabolites produced in the body following the use/consumption of THC-related products. In this research, the THC-COOH metabolite and the enzyme-labeled conjugate compete against each other as the antigens for the system. The antibody used in this assay has a greater affinity for the metabolite; so, as its concentration increases, the absorbance of the system decreases due to less binding of the enzyme-labeled conjugate.   Keyword: Cannabis impaired driving <p /> <p>Language: en</p>",
language="en",
issn="2379-3694",
doi="10.1021/acssensors.9b02020",
url="http://dx.doi.org/10.1021/acssensors.9b02020"
}