@article{ref1,
title="Evaluation of leptin levels in serum as a biomarker for suicide behavior: systematic review and meta-analysis",
journal="International journal of neuroscience",
year="2020",
author="González-Castro, Thelma Beatriz and Almeida de la O, Perla de Los Angeles and Tovilla-Zárate, Carlos Alfonso and López-Narváez, María Lilia and Genis Mendoza, Alma Delia and Juárez-Rojop, Isela Esther and Pérez-Hernández, Nonanzit and Rodríguez-Pérez, José Manuel",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: We conducted a meta-analysis of case-control studies to determine whether leptin levels in serum contribute to the pathogenesis of suicide behavior. <br><br>METHODS: PubMed, EBSCO and Science Direct databases were used to search for relevant articles published before January 2020. The systematic review included nine case-control studies that measured leptin levels. The standardized mean difference (<i>d</i>) and 95% confidence intervals were calculated in a fixed-effects model and a random-effects model when appropriate. <br><br>RESULTS: The results of our meta-analysis indicated that individuals with suicide behavior presented reduced levels of leptin (<i>d</i>: -1.80, 95% CI: -2.21 to -01.38 <i>n</i>g/ml, <i>I</i><sup>2</sup>=0, p(Q)=0.59). Sensitivity and publication bias analyses confirmed these results. <br><br>CONCLUSIONS: The current meta-analysis suggests that leptin levels might be associated with an increased risk of suicide behavior. However, more studies including larger sample sizes are needed to reach conclusive result.<p /> <p>Language: en</p>",
language="en",
issn="0020-7454",
doi="10.1080/00207454.2020.1733558",
url="http://dx.doi.org/10.1080/00207454.2020.1733558"
}