@article{ref1,
title="A behavioral genetic investigation of conceptualizations of resilience in a female twin sample",
journal="Depression and anxiety",
year="2020",
author="Sawyers, Chelsea and Kurtz, Erin D. and Sheerin, Christina and Maes, Hermine H. and Kendler, Kenneth S. and Amstadter, Ananda B.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Great variability exists in response to stressful or traumatic events, leading to an interest in the construct of resilience as a trait and an outcome. The etiologic sources of variability across differing conceptualizations of resilience are poorly understood. <br><br>METHODS: Using behavioral genetic methods in a sample of 2,056 female twins, the present study sought to (a) examine the etiologic sources of a trait-based self-report measure of perceived resilience (PR), (b) determine the genetic and environmental overlap with an outcome-based measure of resilience, as defined by the absence of psychiatric symptoms after stressful life events, previously used by our research team (discrepancy-based psychiatric resilience [DBPR]), and (c) determine the etiologic overlap of these two resilience measures with major depressive disorder (MDD). <br><br>RESULTS: PR was modestly (11%) heritable. A moderate degree of genetic overlap (39%) and a nominal amount of environmental overlap (3%) were found between the two alternative measures of resilience. Genetic factors that influence PR accounted for 3% of MDD heritability, whereas 31% of MDD heritability was due to DBPR genetic factors. <br><br>CONCLUSIONS: Findings of a higher genetic correlation between the outcome-based resilience measure and MDD compared to the trait-based measure and MDD suggest gene-finding efforts may benefit from considering the multifaceted nature of resilience and that resilience is best understood as both a phenotypically and genetically heterogeneous construct.<br><br>© 2020 Wiley Periodicals, Inc.<p /> <p>Language: en</p>",
language="en",
issn="1091-4269",
doi="10.1002/da.23005",
url="http://dx.doi.org/10.1002/da.23005"
}