@article{ref1,
title="Brain volume in veterans: relationship to posttraumatic stress disorder and mild traumatic brain injury",
journal="Journal of head trauma rehabilitation",
year="2020",
author="Martindale, Sarah L. and Rostami, Ramona and Shura, Robert D. and Taber, Katherine H. and Rowland, Jared A.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: Clarify associations between diagnosis of posttraumatic stress disorder (PTSD) and deployment traumatic brain injury (TBI) on salient regional brain volumes in returning combat veterans. PARTICIPANTS: Iraq and Afghanistan era combat veterans, N = 163, 86.5% male. MAIN MEASURES: Clinician-administered PTSD Scale (CAPS-5), Mid-Atlantic MIRECC Assessment of TBI (MMA-TBI), magnetic resonance imaging. <br><br>METHODS: Hierarchical regression analyses evaluated associations and interactions between current and lifetime PTSD diagnosis, deployment TBI, and bilateral volume of hippocampus, anterior cingulate cortex, amygdala, orbitofrontal cortex, precuneus, and insula. <br><br>RESULTS: Deployment TBI was associated with lower bilateral hippocampal volume (P =.007-.032) and right medial orbitofrontal cortex volume (P =.006). Neither current nor lifetime PTSD diagnosis was associated with volumetric outcomes beyond covariates and deployment TBI. <br><br>CONCLUSION: History of deployment TBI is independently associated with lower volumes in hippocampus and medial orbitofrontal cortex. These results support TBI as a potential contributing factor to consider in reduced cortical volume in PTSD.<p /> <p>Language: en</p>",
language="en",
issn="0885-9701",
doi="10.1097/HTR.0000000000000559",
url="http://dx.doi.org/10.1097/HTR.0000000000000559"
}