@article{ref1,
title="Brain metabolic alterations herald falls in patients with Parkinson's disease",
journal="Annals of clinical and translational neurology",
year="2020",
author="Isaias, Ioannis U. and Brumberg, Joachim and Pozzi, Nicoló G. and Palmisano, Chiara and Canessa, Andrea and Marotta, Giorgio and Volkmann, Jens and Pezzoli, Gianni",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="Pathophysiological understanding of gait and balance disorders in Parkinson's disease is insufficient and late recognition of fall risk limits efficacious follow-up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6-8 months before their first fall episode. Falls in Parkinson's disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.<br><br>© 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.<p /> <p>Language: en</p>",
language="en",
issn="2328-9503",
doi="10.1002/acn3.51013",
url="http://dx.doi.org/10.1002/acn3.51013"
}