@article{ref1,
title="Long-term risk of hip or forearm fractures in older occasional users of benzodiazepines",
journal="British journal of clinical pharmacology",
year="2020",
author="Carrier, Hélène and Cortaredona, Sébastien and Philipps, Viviane and Jacqmin-Gadda, Hélène and Tournier, Marie and Verdoux, Helene and Verger, Pierre",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="AIMS: This article sought to study the association between patterns of benzodiazepine (BZD) use and the risk of hip and forearm fractures in people aged 50 and 75 years or more. <br><br>METHODS: In a representative cohort of the French National Health Insurance Fund of individuals aged 50 years or older) (N=106 437), we followed up BZD dispensing (reflecting their patterns of use) and the most frequent fall-related fractures (hip and forearm) for 8 years. We used joint latent class models to simultaneously identify BZD dispensing trajectories and the risk of fractures in the entire cohort and in those 75 years or older). We used a survival model to estimate the adjusted hazard ratios (aHRs) between these trajectories and the risk of fractures. <br><br>RESULTS: In the entire cohort, we identified 5 BZD trajectories: &quot;non-users&quot; (76.7% of the cohort); &quot;occasional users&quot; (15.2%); &quot;decreasing users&quot;(2.6%); &quot;late increasing users&quot; (3.0%); and &quot;early increasing users&quot; (2.4%). Compared with non-users, fracture risk was not increased in either occasional users (aHR = 0.99, 95% CI 0.99-1.00) or in decreasing users (aHR = 0.90, 95% CI 0.74-1.08). It was significantly higher in early increasing users (aHR = 1.86, 95% CI 1.62-2.14) and in late increasing users (aHR = 1.39, 95% CI 1.15-1.60). We observed similar trajectories and risk levels in the people older than 75 years. <br><br>CONCLUSION: Occasional BZD use, which is compatible with current recommendations, was not associated with an excess risk of the most frequent fall-related fractures in people older than 50 or 75 years.<br><br>This article is protected by copyright. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="0306-5251",
doi="10.1111/bcp.14307",
url="http://dx.doi.org/10.1111/bcp.14307"
}