@article{ref1,
title="Fall/fracture-related healthcare costs and their association with cumulative anticholinergic burden in people with overactive bladder",
journal="PharmacoEconomics - open",
year="2020",
author="Lozano-Ortega, Greta and Schermer, Carol R. and Walker, David R. and Szabo, Shelagh M. and Rogula, Basia and Deighton, Alison M. and Gooch, Katherine L. and Campbell, Noll L.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Falls/fractures are major causes of morbidity and mortality among older adults and the resulting health consequences generate a substantial economic burden. Risk factors are numerous and include overactive bladder (OAB) and anticholinergic use. <br><br>OBJECTIVES: We aimed to estimate the impact of falls/fractures on all-cause healthcare resource utilization and costs, according to levels of cumulative anticholinergic burden, among individuals with OAB. <br><br>METHODS: Among a US cohort of adults with OAB (identified based on medical claims for OAB or OAB-specific medications), the frequency of resource utilization (outpatients visits, medication use, and hospitalizations) was examined according to level of anticholinergic burden. Anticholinergic burden was assessed cumulatively using a published measure, and categorized as no, low, medium, or high. Resource utilization prior to and after a fall/fracture was compared. Generalized linear models were used to examine overall and incremental changes in healthcare resource utilization and costs by fall/fracture status, and annual costs were predicted according to age, sex, fall/fracture status, and level of anticholinergic burden. <br><br>RESULTS: The mean age of the OAB cohort (n = 154,432) was 56 years, 68% were female, and baseline mean anticholinergic burden was 266.7 (i.e. a medium level of burden); a fall/fracture was experienced by 9.9% of the cohort. All estimates of resource utilization were higher among those with higher levels of anticholinergic burden, regardless of fall/fracture status, and higher for all levels of anticholinergic burden after a fall/fracture. Among those with a fall/fracture, the highest predicted annual costs were observed among those aged 66-75 years with high anticholinergic burden (US$22,408 for males, US$22,752 for females). <br><br>CONCLUSIONS: Falls/fractures were associated with higher costs, which increased with increasing anticholinergic burden.<p /> <p>Language: en</p>",
language="en",
issn="2509-4262",
doi="10.1007/s41669-020-00215-w",
url="http://dx.doi.org/10.1007/s41669-020-00215-w"
}