@article{ref1,
title="A preliminary investigation of cognitive intolerance and neuroimaging among adolescents returning to school after concussion",
journal="Brain injury",
year="2020",
author="Baker, John G. and Willer, Barry S. and Dwyer, Michael G. and Leddy, John J.",
volume="ePub",
number="ePub",
pages="1-10",
abstract="<b>Primary objective</b>: To introduce the concept of cognitive intolerance. A test is proposed to measure this concept and pilot data are presented to support this measure and future research to develop this concept into a construct. <b>Research design</b>: Three-group comparison to protect larger study blinding. <b>Methods and procedures</b>: Two groups of student athletes (n = 13, n = 13) between 13 and 17 (mean 15.1 ± 1.1 years; 58% male) who sustained a sport-related concussion within 10 days and one group (n = 13) of age-matched healthy controls were recruited for a comparison of correlations between self and observer ratings of cognitive difficulties and DTI fractional anisotropy (FA) using tract-based spatial statistics (TBSS) analysis at two time points. <b>Main outcomes and results</b>: Significant negative only associations (higher cognitive difficulty and lower FA) with DTI FA were found in white matter tracts. These included the anterior corpus callosum, frontal-parietal longitudinal fasciculi, and cortical-subcortical pathways at only the second time point. Several working memory networks would likely involve connections using the above-identified white matter tracts. <b>Conclusions</b>: Cognitive intolerance can be defined as symptom exacerbation from prolonged cognitive activity. Cognitive intolerance could be measured by the n-back working memory task and time to symptom exacerbation.<p /> <p>Language: en</p>",
language="en",
issn="0269-9052",
doi="10.1080/02699052.2020.1749932",
url="http://dx.doi.org/10.1080/02699052.2020.1749932"
}