@article{ref1,
title="Oral cannabidiol does not convert to Δ<sup>8</sup>-THC or Δ<sup>9</sup>-THC in humans: a pharmacokinetic study in healthy subjects",
journal="Cannabis and cannabinoid research",
year="2020",
author="Crippa, José Alexandre S. and Zuardi, Antonio Waldo and Hallak, Jaime Eduardo Cecílio and Miyazawa, Bruna and Bernardo, Sandra Aparecido and Donaduzzi, Carmem Maria and Guzzi, Silvane and Favreto, Wagner Alex Jann and Campos, Alline and Queiroz, Maria Eugênia C. and Guimarães, Francisco S. and da Rosa Zimmermann, Patrícia Moura and Rechia, Letícia Mello and Jose Tondo Filho, Volnei and Brum Junior, Liberato",
volume="5",
number="1",
pages="89-98",
abstract="<b>Introduction:</b> Recent studies have suggested that cannabidiol (CBD) could interconvert into Delta-8- and Delta-9- tetrahydrocannabinol. <b>Materials and Methods:</b> Thus, we tested the plasma samples of 120 healthy human subjects (60 male and 60 female), 60 in fasting and the other 60 under normal feeding conditions after acute administration of an oral solution containing CBD 300 mg. To do this, we developed a bioanalytical method to determine CBD and the presence of THC in plasma samples by Ultra-High Performance Liquid Chromatography Coupled to Tandem Mass Spectrometry. <b>Results:</b> The results showed that THC was not detected in plasma after the administration of CBD, and those study participants did not present psychotomimetic effects. <b>Conclusions:</b> The findings presented here are consistent with previous evidence suggesting that the oral administration of CBD in a corn oil formulation is a safe route for the administration of the active substance without bioconversion to THC in humans.<br><br>Copyright 2020, Mary Ann Liebert, Inc., publishers.<p /> <p>Language: en</p>",
language="en",
issn="2578-5125",
doi="10.1089/can.2019.0024",
url="http://dx.doi.org/10.1089/can.2019.0024"
}