@article{ref1,
title="Neighborhood deprivation moderates shared and unique environmental influences on hazardous drinking: findings from a cross-sectional co-twin study",
journal="Substance use and misuse",
year="2020",
author="Rhew, Isaac C. and Fleming, Charles B. and Tsang, Siny and Horn, Erin and Kosterman, Rick and Duncan, Glen E.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="<i>Background:</i> There has been increased interest in the interplay of genetic and environmental factors in the development of problematic alcohol use, including socioeconomic conditions of the neighborhood. Using a co-twin design, we examined the extent to which contributions of genetic, shared environmental, and unique environmental influences on hazardous drinking differed according to levels of neighborhood socioeconomic deprivation. <i>Method:</i> Data came from 1,521 monozygotic (MZ) and 609 dizygotic (DZ) twin pairs surveyed in Washington State. A measure of neighborhood deprivation was created based on census-tract-level variables and the Alcohol Use Disorders Identification Test 3-item instrument was used to assess level of hazardous drinking. We tested a series of nested structural equation models to examine associations among hazardous drinking, neighborhood deprivation, and the variance components (genetic [A], shared [C] and unique environmental [E] influences) of these two constructs, testing for both main effects and moderation by neighborhood deprivation. <i>Results:</i> Neighborhood deprivation was significantly associated with increased hazardous drinking, after accounting for A and C variance common to both phenotypes. Adjusting for within-pair differences in income and education, neighborhood deprivation moderated the magnitude of variance components of hazardous drinking, with the variance attributable to shared environment and non-shared environment increasing in more deprived neighborhoods. <i>Conclusions:</i> Findings point to amplification of early childhood as well as unique adulthood environmental risk on hazardous drinking in areas of greater deprivation.<p /> <p>Language: en</p>",
language="en",
issn="1082-6084",
doi="10.1080/10826084.2020.1756332",
url="http://dx.doi.org/10.1080/10826084.2020.1756332"
}