@article{ref1,
title="Smaller feedback-related negativity (FRN) reflects the risky decision-making deficits of methamphetamine dependent individuals",
journal="Frontiers in psychiatry",
year="2020",
author="Zhong, Na and Chen, Tianzhen and Zhu, Youwei and Su, Hang and Ruan, Xiaolu and Li, Xiaotong and Tan, Haoye and Jiang, Haifeng and Du, Jiang and Zhao, Min",
volume="11",
number="",
pages="e320-e320",
abstract="Methamphetamine (MA) chronic users show risky decision-making deficits. However, the neural mechanisms underlying these deficits remain unclear. A case-control study was conducted to understand how MA users and healthy controls differ in electrophysiological responses associated with series decision-making. Electroencephalography of 31 MA users and 27 healthy controls was recorded when they performed the Balloon Analogue Risk Task involving risky decision-making with uncertain gain or loss. Feedback-related negativity (FRN) was measured and their association with their risky decision-making and impulsivity were examined. Compared to healthy controls, MA users showed smaller peak FRN amplitudes in fronto-central electrodes (F <sub>(1,</sub><sub>56)</sub> =4.559, p=0.037), and the attenuated peak FRN amplitudes correlated with more risk-taking behavior (r=0.48, p=0.012). Besides, MA users exhibited later FRN (F <sub>(1,</sub><sub>56)</sub> = 7.561, p=0.008) and earlier P300 (F <sub>(1,</sub><sub>56)</sub> = 3.582, p = 0.041) compared to healthy controls in fronto-central electrodes, which were correlated with higher score of impulsivity. These findings provided further evidence that MA users showed insensitivity to negative feedback in risky decision-making. FRN might be a promising biomarker of dependence.<br><br>Copyright © 2020 Zhong, Chen, Zhu, Su, Ruan, Li, Tan, Jiang, Du and Zhao.<p /> <p>Language: en</p>",
language="en",
issn="1664-0640",
doi="10.3389/fpsyt.2020.00320",
url="http://dx.doi.org/10.3389/fpsyt.2020.00320"
}