@article{ref1,
title="Walking and cognitive performance in adults with multiple sclerosis: do age and fatigability matter?",
journal="Multiple sclerosis and related disorders",
year="2020",
author="Jones, C. Danielle and Cederberg, Katie L. and Sikes, E. Morghen and Wylie, Glenn R. and Motl, Robert W. and Sandroff, Brian M.",
volume="42",
number="",
pages="e102136-e102136",
abstract="BACKGROUND: Co-occurring walking and cognitive performance deficits are debilitating consequences of multiple sclerosis (MS) that worsen with age. However, it is unknown if fatigability influences such age-related worsening of walking and cognitive performance. <br><br>OBJECTIVE: This cross-sectional study examined possible age-related differences in walking-related motor fatigability (incremental six-minute-walk (6MW) performance) and cognitive fatigability (incremental Symbol Digit Modalities Test (SDMT) performance) in adults with MS. <br><br>METHODS: 196 adults with MS were categorized into age-groups: younger (20-39 years; n = 53), middle-aged (40-59 years; n = 89), and older (60-79 years; n = 54), and completed the 6MW and SDMT. Age-group differences in incremental 6MW and SDMT performance, controlling for disability status, were examined using separate, mixed-factor ANCOVAs. <br><br>RESULTS: There were no statistically significant age-group-by-time interactions on walking-related motor or cognitive fatigability when controlling for disability. However, there were significant main effects of time on incremental 6MW (p = 0.01) and SDMT (p < 0.01) performance indicating the presence of walking-related motor and cognitive fatigability, respectively, collapsed across age-groups. <br><br>CONCLUSION: Fatigability does not exert a primary influence on age-related worsening of walking and cognitive neuroperformance outcomes among adults with MS. This suggests that walking-related motor fatigability and cognitive fatigability may not be optimal targets for mitigating age-related declines in ambulation and cognition among adults with MS.<br><br>Copyright © 2020 Elsevier B.V. All rights reserved.<p /> <p>Language: en</p>",
language="en",
issn="2211-0348",
doi="10.1016/j.msard.2020.102136",
url="http://dx.doi.org/10.1016/j.msard.2020.102136"
}