@article{ref1,
title="The (broad-sense) genetic correlations among four measures of inattention and hyperactivity in 12 year olds",
journal="Behavior genetics",
year="2020",
author="Dolan, Conor V. and de Zeeuw, Eveline L. and Zayats, Tetyana and van Beijsterveldt, C. E. M. and Boomsma, Dorret I.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="We estimated the genetic covariance matrix among four inattention (INATT) and four hyperactivity (HYP) measures in the classical twin design. Data on INATT and HYP symptom counts were obtained in mono- and dizygotic twin pairs (N = 1593) with an average age of 12.2 years (sd = .51). We analyzed maternal ratings of INATT and HYP based on the Conners' Parent Rating Scale (CPRS), the Strengths and Weaknesses of ADHD-symptoms and Normal-behavior (SWAN), and teacher ratings based on the Conners' Teacher rating scale (CTRS) and the ASEBA Teacher Rating Form (TRF). Broad-sense heritabilities, corrected for the main effects of sex and for random teacher rater effects, were large (ranging from.658 to.912). The results reveal pervasive and strong broad-sense genetic effects on INATT and HYP phenotypes with the phenotypic covariance among the phenotypes largely due to correlated genetic effects. Specifically between 79.9 and 99.9% of the phenotypic covariance among the HYP measures, and between 81.0 and 93.5% of the INATT measures are attributable to broad-sense genetic effects. Overall, the present results, pertaining to the broad-sense heritabilities and shared genetic effects, support the current genome-wide association meta-analytic approach to identifying pleiotropic genetic variants.<p /> <p>Language: en</p>",
language="en",
issn="0001-8244",
doi="10.1007/s10519-020-10002-2",
url="http://dx.doi.org/10.1007/s10519-020-10002-2"
}