@article{ref1,
title="Clinical factors associated with suicide risk independent of depression in persons with epilepsy",
journal="Seizure",
year="2020",
author="Kim, Soo Jeong and Kim, Hyo Jae and Jeon, Ji-Ye and Kim, Hyun-Woo and Lee, Sang-Ahm",
volume="80",
number="",
pages="86-91",
abstract="PURPOSE: We determined whether factors related to epilepsy are associated with a risk of suicide independent of depression in persons with epilepsy.  METHOD: This cross-sectional study included adults with epilepsy. Suicidality and depression were assessed with the Mini International Neuropsychiatric Interview (MINI). Patients were divided into two age groups (≤ 40 vs. > 40 years). Presence of suicide risk was defined as a MINI suicidality score ≥ 1. A stepwise logistic regression analysis was conducted.  RESULTS: A total of 212 participants were recruited (52.4 % men). Suicide risk and depression were noted in 31.6 % and 22.2 % of participants, respectively. An antiepileptic drug load ≥ 1 (odds ratio [OR], 4.093-4.152) was significantly associated with a risk of suicide, independent of depression (OR, 5.794), and a past or family history of psychiatric disorders (OR, 2.677). When stratified by age, pregabalin usage (OR, 13.403) in the younger group and high seizure frequency (≥ 1 per month) (OR, 5.748) in the older group were associated with a risk of suicide independent of current depression.  CONCLUSION: The risk of suicide in persons with epilepsy may be associated with epilepsy-related factors such as a high antiepileptic drug load, frequent seizures, and use of pregabalin, independent of depression. Such risk factors may vary depending on the age of the patient.<p /> <p>Language: en</p>",
language="en",
issn="1059-1311",
doi="10.1016/j.seizure.2020.05.026",
url="http://dx.doi.org/10.1016/j.seizure.2020.05.026"
}