@article{ref1,
title="Repeated long-term sub-concussion impacts induce motor dysfunction in rats: a potential rodent model",
journal="Frontiers in neurology",
year="2020",
author="Lavender, Andrew P. and Rawlings, Samuel and Warnock, Andrew and McGonigle, Terry and Hiles-Murison, Bailey and Nesbit, Michael and Lam, Virginie and Hackett, Mark J. and Fitzgerald, Melinda and Takechi, Ryusuke",
volume="11",
number="",
pages="e491-e491",
abstract="Whilst detrimental effects of repeated sub-concussive impacts on neurophysiological and behavioral function are increasingly reported, the underlying mechanisms are largely unknown. Here, we report that repeated sub-concussion with a light weight drop (25 g) in wild-type PVG rats for 2 weeks does not induce detectable neuromotor dysfunction assessed by beamwalk and rotarod tests. However, after 12 weeks of repeated sub-concussion, the rats exhibited moderate neuromotor dysfunction. This is the first study to demonstrate development of neuromotor dysfunction following multiple long-term sub-concussive impacts in rats. The outcomes may offer significant opportunity for future studies to understand the mechanisms of sub-concussion-induced neuropsychological changes.<p /> <p>Language: en</p>",
language="en",
issn="1664-2295",
doi="10.3389/fneur.2020.00491",
url="http://dx.doi.org/10.3389/fneur.2020.00491"
}