@article{ref1,
title="Neurophysiological markers of cognitive deficits and recovery in concussed adolescents",
journal="Brain research",
year="2020",
author="Ruiter, Kyle I. and Boshra, Rober and DeMatteo, Carol and Noseworthy, Michael and Connolly, John F.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: The present study sought to determine: 1) whether concussed adolescents exhibited deficits in neurocognitive functioning as reflected by neurophysiological alterations; 2) if neurophysiological alterations could be linked to supplementary data such as the number of previous concussions and days since injury; and 3) if deficits in psychological health and behavioural tests increased during diagnosis duration.   METHODS: Twenty-six concussed adolescents were compared to twenty-eight healthy controls with no prior concussions. Self-report inventories evaluated depressive and concussive symptomatology, while behavioral tests evaluated cognitive ability qualitatively. To assess neurophysiological markers of cognitive function, two separate auditory oddball tasks were employed: 1) an active oddball task measuring executive control and attention as reflected by the N2b and P300, respectively; and 2) a passive oddball task assessing the early, automatic pre-conscious awareness processes as reflected by the MMN.   RESULTS: Concussed adolescents displayed delayed N2b and attenuated P300 responses relative to controls; showed elevated levels of depressive and concussive symptomatology; scored average-to- low-average in behavioral tests; and exhibited N2b response latencies that correlated with number of days since injury.   CONCLUSION: These findings demonstrate that concussed adolescents exhibit clear deficiencies in neurocognitive function, and that N2b response latency may be a marker of concussion recovery.<p /> <p>Language: en</p>",
language="en",
issn="0006-8993",
doi="10.1016/j.brainres.2020.146998",
url="http://dx.doi.org/10.1016/j.brainres.2020.146998"
}