@article{ref1,
title="Vitamin D megadose: definition, efficacy in bone metabolism, risk of falls and fractures",
journal="Open access rheumatology : research and reviews",
year="2020",
author="Narvaez, Jemina and Maldonado, Genessis and Guerrero, Roberto and Messina, Osvaldo Daniel and Rios, Carlos",
volume="12",
number="",
pages="105-115",
abstract="INTRODUCTION: Currently, approximately more than one billion people around the world are considered to have deficient levels of vitamin D. International consensus recommends vitamin D supplementation to high-risk patients (advanced age, osteoporosis, liver failure, malabsorption syndromes, etc.) and those with levels below 30 ng/mL. There are several vitamin D formulations and dosages available, including megadoses. At the moment, there is no consensus on the definition of megadoses.   The purpose of this review is to define what is a megadose and analyze its effectiveness in bone metabolism, risk of fractures and falls.   Conclusion: The administration of doses higher than 100,000 IU of vitamin D is considered a megadose. It is evident that the use of megadoses increases serum concentrations of vitamin D; however, there has been no evidence of a decrease in the risk of falls, vertebral fractures or changes in bone mineral density.<p /> <p>Language: en</p>",
language="en",
issn="1179-156X",
doi="10.2147/OARRR.S252245",
url="http://dx.doi.org/10.2147/OARRR.S252245"
}