@article{ref1,
title="The effects of callous-unemotional traits and aggression subtypes on amygdala activity in response to negative faces",
journal="Psychological medicine",
year="2020",
author="Aggensteiner, Pascal-M. and Holz, Nathalie E. and Böttinger, Boris W. and Baumeister, Sarah and Hohmann, Sarah and Werhahn, Julia E. and Naaijen, Jilly and Ilbegi, Shahrzad and Glennon, Jeffrey C. and Hoekstra, Pieter J. and Dietrich, Andrea and Deters, Renee Kleine and Saam, Melanie C. and Schulze, Ulrike M. E. and Lythgoe, David J. and Sethi, Arjun and Craig, Michael C. and Mastroianni, Mathilde and Sagar-Ouriaghli, Ilyas and Santosh, Paramala J. and Rosa, Mireia and Bargalló, Nuria and Castro-Fornieles, Josefina and Arango, Celso and Penzol, Maria J. and Vidal, Jorge and Franke, Barbara and Zwiers, Marcel P. and Buitelaar, Jan K. and Walitza, Susanne and Banaschewski, Tobias and Brandeis, Daniel",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Brain imaging studies have shown altered amygdala activity during emotion processing in children and adolescents with oppositional defiant disorder (ODD) and conduct disorder (CD) compared to typically developing children and adolescents (TD). Here we aimed to assess whether aggression-related subtypes (reactive and proactive aggression) and callous-unemotional (CU) traits predicted variation in amygdala activity and skin conductance (SC) response during emotion processing.   METHODS: We included 177 participants (n = 108 cases with disruptive behaviour and/or ODD/CD and n = 69 TD), aged 8-18 years, across nine sites in Europe, as part of the EU Aggressotype and MATRICS projects. All participants performed an emotional face-matching functional magnetic resonance imaging task.   RESULTS: Differences between cases and TD in affective processing, as well as specificity of activation patterns for aggression subtypes and CU traits, were assessed. Simultaneous SC recordings were acquired in a subsample (n = 63). Cases compared to TDs showed higher amygdala activity in response to negative faces (fearful and angry) v. shapes. Subtyping cases according to aggression-related subtypes did not significantly influence on amygdala activity; while stratification based on CU traits was more sensitive and revealed decreased amygdala activity in the high CU group. SC responses were significantly lower in cases and negatively correlated with CU traits, reactive and proactive aggression.   CONCLUSIONS: Our results showed differences in amygdala activity and SC responses to emotional faces between cases with ODD/CD and TD, while CU traits moderate both central (amygdala) and peripheral (SC) responses. Our insights regarding subtypes and trait-specific aggression could be used for improved diagnostics and personalized treatment.<p /> <p>Language: en</p>",
language="en",
issn="0033-2917",
doi="10.1017/S0033291720002111",
url="http://dx.doi.org/10.1017/S0033291720002111"
}