@article{ref1,
title="Comorbid anxiety and suicidal behaviors in American adolescents with major depression",
journal="Curēus",
year="2020",
author="Mathialagan, Keerthika and Ceren Amuk, Ozge and Eskander, Noha and Patel, Rikinkumar S.",
volume="12",
number="6",
pages="e8598-e8598",
abstract="OBJECTIVE The aim of this study was to evaluate the odds of association between suicidal behaviors and comorbid anxiety disorders in adolescents with major depressive disorder (MDD). <br><br>METHODS We included 122,020 adolescent inpatients with MDD from the Nationwide Inpatient Sample (NIS) and further grouped them by co-diagnosis of anxiety disorders. Logistic regression analysis was used to evaluate the odds ratio (OR) of suicidal behaviors due to comorbid anxiety disorders. <br><br>RESULTS Out of total MDD inpatients, 45.8% had comorbid anxiety disorders. Around 53.5% MDD inpatients with anxiety disorders had suicidal behaviors, which were significantly higher than seen in 52.6% non-anxiety cohort (P = 0.002). Comorbid anxiety disorders had a minimally positive association with suicidal behaviors and were not statistically significant (OR: 1.01; P = 0.710) after controlling the logistic regression analysis for demographic confounders and psychiatric comorbidities. MDD inpatients with comorbid psychotic disorders were positively associated (OR: 1.16; P = 0.007) with suicidal behaviors. <br><br>CONCLUSIONS MDD with comorbid anxiety had a statistically non-significant association with suicidal behaviors in adolescents. Depression has a direct and independent effect on adolescent suicidal behaviors, whereas anxiety has a direct effect only on perpetuating depression. Early diagnosis and management of comorbid anxiety and psychosis with MDD reduce functional impairment and suicide risk in at-risk populations.<p /> <p>Language: en</p>",
language="en",
issn="2168-8184",
doi="10.7759/cureus.8598",
url="http://dx.doi.org/10.7759/cureus.8598"
}