@article{ref1,
title="The role of the 5-HTTLPR polymorphism in acquired capability for suicide",
journal="Suicide and life-threatening behavior",
year="2020",
author="Wannemueller, André and Forkmann, Thomas and Glaesmer, Heide and Juckel, Georg and Paashaus, Laura and Rath, Dajana and Schönfelder, Antje and Moser, Dirk and Kumsta, Robert and Teismann, Tobias",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: According to the Interpersonal Psychological Theory of Suicide, capability for suicide comprises two dimensions: fearlessness about death and elevated pain tolerance. The short (S) allelic variant of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has repeatedly been associated with more violent and lethal suicide methods and lethality of suicide attempts. The current study aimed to investigate whether 5-HTTLPR allelic variants are associated with fearlessness about death and pain tolerance/persistence and whether it moderates the relationship between childhood maltreatment and acquired capability for suicide.   METHOD: A cohort of 208 inpatients hospitalized due to a recent suicide attempt or severe suicidal ideation was genotyped for the 5-HTTLPR and assessed for childhood maltreatment. Subjective pain tolerance and fearlessness about death as well as objective pain persistence was assessed using a pressure algometer.   RESULTS: Fearlessness about death, pain tolerance, and pain persistence did not differ between 5-HTTLPR genotypes. However, there was a significant correlation between self-reported childhood maltreatment and fearlessness about death that emerged exclusively in homozygous S-allele carriers.   CONCLUSION: Results suggest that there are no &quot;high-risk&quot;-alleles that generally increase capability for suicide. However, in terms of future suicide-related behaviors exposure to childhood maltreatment events could exert a particularly negative influence on homozygous S-allele carriers by increasing their fearlessness about death.<p /> <p>Language: en</p>",
language="en",
issn="0363-0234",
doi="10.1111/sltb.12660",
url="http://dx.doi.org/10.1111/sltb.12660"
}