@article{ref1,
title="Impact of number of drugs on rehabilitation outcomes in patients after traumatic brain injury: a retrospective cohort study",
journal="PM & R : the journal of injury, function, and rehabilitation",
year="2020",
author="Yamaoka, Makiko and Chono, Masayuki and Fukumoto, Miki and Watanabe, Tomomi and Fukaya, Takeshi and Momosaki, Ryo",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="OBJECTIVE: The aim of this study was to investigate the impact of the number of drugs on rehabilitation outcomes for patients with acute traumatic brain injury.   DESIGN: Retrospective cohort study.   SETTING: Hospital-based database created by the Japan Medical Data Center.   PARTICIPANTS: Patients with acute traumatic brain injuryadmittedbetween April 2014 and November 2017.   METHODS: Analysis of relationships among 1-5 and ≥6 drugs as well as clinical outcomes in 2603 patients.   MAIN OUTCOME MEASUREMENTS: The primary outcome was defined as the Barthel index efficiency, and the secondary outcome was Barthel index gain and length of hospital stay.   RESULTS: Median Barthel index score on admission was 40. Barthel index efficiency and Barthel index gain were significantly higher in the group that had taken 1-5 drugs than in the group that had taken ≥6 drugson admission (median: 1.19 vs 0.50, 20.0 vs 10.0). Also, the group that had taken 1-5 drugshad a significantly shorter length of hospital stay than in the group that had taken ≥6 drugson admission (median 11.0 vs 14.0). Moreover, multiple linear regression analysis showed that having taken ≥6 drugs on admission was independently associated with Barthel index efficiency, Barthel index gain, and length of stay.   CONCLUSIONS: Taking≥6 drugs for acute traumatic brain injury was associated with lower Barthel index efficiency,lower Barthel index gain, and longer length of stay than taking 1-5 drugs.<p /> <p>Language: en</p>",
language="en",
issn="1934-1482",
doi="10.1002/pmrj.12460",
url="http://dx.doi.org/10.1002/pmrj.12460"
}