@article{ref1,
title="Falls associate with neurodegenerative changes in ATN framework of Alzheimer's disease",
journal="Journal of Alzheimer's disease",
year="2020",
author="Keleman, Audrey and Wisch, Julie K. and Bollinger, Rebecca M. and Grant, Elizabeth A. and Benzinger, Tammie L. and Morris, John C. and Ances, Beau M. and Stark, Susan L.",
volume="ePub",
number="ePub",
pages="ePub-ePub",
abstract="BACKGROUND: Behavioral markers for Alzheimer's disease (AD) are not included within the widely used amyloid-tau-neurodegeneration framework.   OBJECTIVE: To determine when falls occur among cognitively normal (CN) individuals with and without preclinical AD.   METHODS: This cross-sectional study recorded falls among CN participants (n = 83) over a 1-year period. Tailored calendar journals recorded falls. Biomarkers including amyloid positron emission tomography (PET) and structural and functional magnetic resonance imaging were acquired within 2 years of fall evaluations. CN participants were dichotomized by amyloid PET (using standard cutoffs). Differences in amyloid accumulation, global resting state functional connectivity (rs-fc) intra-network signature, and hippocampal volume were compared between individuals who did and did not fall using Wilcoxon rank sum tests. Among preclinical AD participants (amyloid-positive), the partial correlation between amyloid accumulation and global rs-fc intra-network signature was compared for those who did and did not fall.   RESULTS: Participants who fell had smaller hippocampal volumes (p = 0.04). Among preclinical AD participants, those who fell had a negative correlation between amyloid uptake and global rs-fc intra-network signature (R = -0.75, p = 0.012). A trend level positive correlation was observed between amyloid uptake and global rs-fc intra-network signature (R = 0.70, p = 0.081) for preclinical AD participants who did not fall.   CONCLUSION: Falls in CN older adults correlate with neurodegeneration biomarkers. Participants without falls had lower amyloid deposition and preserved global rs-fc intra-network signature. Falls most strongly correlated with presence of amyloid and loss of brain connectivity and occurred in later stages of preclinical AD.<p /> <p>Language: en</p>",
language="en",
issn="1387-2877",
doi="10.3233/JAD-200192",
url="http://dx.doi.org/10.3233/JAD-200192"
}